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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Saikosaponin D inhibits the inflammatory response of secretory otitis media through FTO-mediated N6-methyladenosine modification of TLR4 mRNA

Fig. 3

SSD suppresses effects of FTO knockdown on bacterial clearance. A qPCR analysis of FTO levels in middle ears of rats injected with LV-shNC or LV-shFTO, and two SSD treated rats injected with LV-shNC or LV-shFTO. B&C Western blot analysis of FTO levels in middle ears of rats injected with LV-shNC or LV-shFTO, and two SSD treated rats injected with LV-shNC or LV-shFTO. D HE staining images of middle ears of rats injected with LV-shNC or LV-shFTO, and two SSD treated rats injected with LV-shNC or LV-shFTO, scalr bars: 200 μm. E ELISA was performed to evaluate TNF-α, IL-6 and INF-γ levels in MELF collected from rats injected with LV-shNC or LV-shFTO, and two SSD treated rats injected with LV-shNC or LV-shFTO. F CFUs per milliliter, and neutrophils number in the MELF collected from rats injected with LV-shNC or LV-shFTO, and two SSD treated rats injected with LV-shNC or LV-shFTO. *p < 0.05, **p < 0.01, ***p < 0.001

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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