Table 4 The top 30 signal strength of adverse events of rotigotine ranked by the number of case reports at the PTs level in FAERS database

Product Adhesion Issue*

1336

115.28 (108.94–121.98)

108.46 (135850.43)

103.57 (98.79)

6.69 (5.03)

Drug Ineffective*

651

1.32 (1.22–1.43)

1.31 (50.04)

1.31 (1.23)

0.39 (-1.27)

Death*

529

1.67 (1.53–1.82)

1.65 (137.14)

1.65 (1.53)

0.72 (-0.94)

Off Label Use*

437

1.46 (1.33–1.6)

1.45 (62.01)

1.45 (1.34)

0.54 (-1.13)

Application Site Pruritus*

417

50.28 (45.59–55.46)

49.37 (19348.15)

48.34 (44.54)

5.6 (3.93)

Application Site Erythema*

409

41.5 (37.6–45.81)

40.77 (15592.76)

40.07 (36.89)

5.32 (3.66)

Device Adhesion Issue*

383

75.95 (68.54–84.16)

74.67 (26959.86)

72.33 (66.38)

6.18 (4.51)

Fall*

361

2.93 (2.64–3.25)

2.9 (451.76)

2.9 (2.66)

1.54 (-0.13)

Parkinson’S Disease*

345

51.57 (46.31–57.42)

50.79 (16476.71)

49.7 (45.43)

5.64 (3.97)

Overdose*

334

4.01 (3.59–4.46)

3.96 (740.61)

3.96 (3.61)

1.98 (0.32)

Tremor*

308

5.01 (4.48–5.61)

4.96 (974)

4.95 (4.51)

2.31 (0.64)

Dizziness*

249

1.35 (1.2–1.53)

1.35 (22.84)

1.35 (1.22)

0.43 (-1.23)

Insomnia*

245

2.46 (2.17–2.79)

2.45 (210.31)

2.45 (2.2)

1.29 (-0.38)

Hallucination*

233

8.7 (7.64–9.9)

8.62 (1564.37)

8.59 (7.71)

3.1 (1.44)

Nausea

224

0.77 (0.67–0.87)

0.77 (15.69)

0.77 (0.69)

-0.38 (-2.04)

Application Site Reaction*

215

98.76 (86.11–113.28)

97.82 (19756.77)

93.83 (83.66)

6.55 (4.89)

Restless Legs Syndrome*

210

30.74 (26.81–35.24)

30.46 (5905.93)

30.07 (26.82)

4.91 (3.24)

Somnolence*

199

2.69 (2.34–3.1)

2.68 (209.82)

2.68 (2.38)

1.42 (-0.25)

Application Site Rash*

191

35 (30.32–40.4)

34.71 (6159.97)

34.2 (30.33)

5.1 (3.43)

Gait Disturbance*

169

2.28 (1.96–2.65)

2.27 (120.64)

2.27 (2)

1.18 (-0.48)

Pneumonia*

164

1.39 (1.19–1.62)

1.38 (17.6)

1.38 (1.22)

0.47 (-1.2)

Wrong Technique In Product Usage Process*

160

2.15 (1.84–2.51)

2.14 (97.65)

2.14 (1.88)

1.1 (-0.57)

Anxiety*

159

1.47 (1.26–1.72)

1.47 (23.73)

1.47 (1.29)

0.55 (-1.11)

Fatigue

152

0.52 (0.44–0.61)

0.52 (66.3)

0.52 (0.46)

-0.93 (-2.6)

Vomiting

140

0.82 (0.69–0.97)

0.82 (5.59)

0.82 (0.71)

-0.29 (-1.95)

Pain

140

0.59 (0.5–0.69)

0.59 (40.4)

0.59 (0.51)

-0.76 (-2.43)

Intentional Product Misuse*

139

4.2 (3.56–4.97)

4.18 (336.66)

4.18 (3.63)

2.06 (0.4)

Asthenia

137

0.99 (0.83–1.17)

0.99 (0.03)

0.99 (0.86)

-0.02 (-1.69)

Pruritus

137

1.05 (0.89–1.24)

1.05 (0.35)

1.05 (0.91)

0.07 (-1.59)

Dysphagia*

128

3.7 (3.11–4.4)

3.68 (249.92)

3.68 (3.18)

1.88 (0.21)