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Table 1 Age, gender, BWT, risk factors, comorbidities, history of cardiac events, previous coronary procedures, GDMT, ABP, EF, the baseline GDMT, the baseline sCr, CrCl, and eGFR in both groups

From: Trimetazidine effect on kidney function in patients undergoing coronary procedures

items

Group I

(No.=205)

Group II (No.=205)

Test

P-value

SMD

After applying IPW

Age (mean ± SD)

58.2 ± 10.8

57.3 ± 10.7

Independent T-test

0.405

0.084

Gender

Male

Female

158(77.1%)

47(22.9%)

156(76.1%)

49(23.9%)

Chi-squared test

0.816

0.024

BWT (mean ± SD)

33.9 ± 8.7

32.5 ± 7.6

Independent T-test

0.447

0.050

HTN

176(85.9%)

170(82.9%)

Chi-squared test

0.414

0.040

Dyslipidemia

175(85.4%)

163(79.5%)

0.119

0.080

Smoking

122(59.5%)

128(62.4%)

0.544

0.060

DM

120(58.5%)

114(55.6%)

0.549

0.060

PVD

85(41.5%)

92(44.9%)

0.485

0.069

CVS

82(40.0%)

71(34.6%)

0.261

0.111

History of UA

137(66.8%)

146(71.2%)

0.336

0.095

History of MI

97(47.3%)

98(47.8%)

0.921

0.010

History of PCI

107(52.2%)

101(49.3%)

0.553

0.058

History of CABG

64(31.2%)

57(27.8%)

0.448

0.075

EF

53.5 ± 15.2

52.7 ± 13.7

Independent T-test

0.645

0.055

 

SBP

150.3 ± 14.8

147.4 ± 16.5

0.061

0.090

 

DBP

87.2 ± 10.3

87.1 ± 11.7

0.925

0.009

 

sCr

1.2 ± 0.2

1.2 ± 0.20

0.565

0.000

CrCl

61.9 ± 14.7

60.7 ± 15

0.416

0.081

eGFR

53 ± 12

53.5 ± 12.7

0.974

0.040

GDMT

ACEI (Ramipril)

91(44.4%)

86(42%)

Chi-squared test

0.486

0.049

ARBs (Valsartan)

83(40.5%)

72(35.1%)

0.362

0.111

SGLT2I (Dapagliflozin)

130(63.4%)

142(69.3%)

0.337

0.337

BB (Bisoprolol)

96(46.8%)

97(47.3%)

0.923

0.010

Statins (Rosuvastatin)

180(87.8%)

175(85.4%)

0.518

0.069

Dual antiplatelet (Aspirin 81 and clopidogrel 75 mg)

182(88.8%)

176(85.9%)

0.319

0.087

  1. DM: Diabetes mellitus, GDMT: Guidelines Directed Medical Therapy, BWT: Body Weight, SD: Standard Deviation, UA: Unstable angina, MI: myocardial infarction, PCI: percutaneous coronary intervention, CABG: coronary artery bypass grafting, ABP: Arterial Blood Pressure EF: Ejection Fraction, SBP: Systolic Blood Pressure, PVD: Peripheral Vascular Disease, CVS: Cerebrovascular Stroke, HTN: Hypertension, DBP: Diastolic Blood Pressure, ACEI Angiotensin Converting Enzyme Inhibitor, ARBs: Angiotensinogen Receptor Blocker, BB: Beta Blockers CrCl: Creatinine Clearance, SCr: Serum Creatinine, eGFR: estimated Glomerular Filtration Rate, SMDs: Standardized Mean Differences, IPW Inverse Probability Weighting, SMDs were calculated to assess the baseline balance between groups. An SMD < 0.1 indicates a negligible imbalance