Trimetazidine effect on kidney function in patients undergoing coronary procedures

Table 4 Multivariable logistic regression for CIN after three days

Independent variable	P-value Unadjusted	P- Value Bonferroni	P -Value FDR	OR	95% C.I. for OR
Independent variable	P-value Unadjusted	P- Value Bonferroni	P -Value FDR	OR	Lower	Upper
TMZ	0.044*	0.352	0.088	0.571	0.331	0.986
Contrast amount	0.499	> 0.999	0.544	1.003	0.995	1.010
Baseline eGFR	0.544	> 0.999	0.544	1.006	0.986	1.028
Age	0.179	> 0.999	0.299	0.982	0.957	1.008
Female gender	0.274	> 0.999	0.343	0.686	0.349	1.348
DM	0.947	> 0.999	0.947	0.982	0.576	1.676
HTN	0.209	> 0.999	0.299	0.617	0.290	1.311
Baseline sCr	0.271	> 0.999	0.343	0.499	0.144	1.721
Correlation (TMZ Vs contrast)	0.007^*	0.056	0.017*	R= -0.187

TMZ: Trimetazidine, HTN: Hypertension, DM: Diabetes mellitus
eGFR: estimated Glomerular Filtration Rate, sCr: Serum Creatinine
*P-value is significant, R: Pearson correlation
*Bonferroni-adjusted α = 0.002 (0.05/25); FDR-adjusted p-values calculated using Benjamini-Hochberg method. TMZ p = 0.044 and correlation p = 0.007 not significant at Bonferroni α = 0.002 but retain borderline significance with FDR

ISSN: 2050-6511