Fig. 2

Identification and analysis of DEGs and ENU-induced glioma targets. DEGs were identified from glioma datasets GSE16011 (A) and GSE4290 (B). The x-axis denotes log2-transformed fold changes and the y-axis denotes the negative log10-transformed adjusted p-values (Padj). Red dots represent upregulated genes, blue dots indicate downregulated genes and grey dots denote non-significant genes. (C) Venn diagram illustrating the overlap between glioma DEGs and ENU targets, identifying 71 common genes implicated in ENU-induced glioma. (D) PPI network of the 71 ENU-induced glioma targets. Red nodes indicate hub genes and yellow nodes represent other interacting genes