Table 4 Logistic regression analysis for risk factors associated with actual drug-drug interactions in ICU patients
Variable | With actual DDIs (n = 46) | Without actual DDIs (n = 415) | p |
|---|---|---|---|
Age,years | 72 (50, 77.5) | 57.5 (44, 70) | 0.135 |
Age, ≧65 | 20 (43.48%) | 157 (37.83%) | 0.447 |
Gender, male(%) | 25 (54.35%) | 209 (50.36%) | 0.597 |
ICU length of stay, days | 16.75 (5.25, 21) | 14 (5, 14.5) | 0.047 |
APACHE II score | 17.5 (12.25, 21) | 15 (15, 22) | 0.466 |
Comorbidity | |||
 Cardiovascular diseases | 29 (63.04%) | 223 (53.73%) | 0.223 |
 Endocrine disorders | 15 (32.61%) | 122 (29.4%) | 0.644 |
 Pulmonary disease | 18 (39.13%) | 159 (38.31%) | 0.904 |
 Chronic kidney diseases | 7 (15.21%) | 56 (13.49%) | 0.742 |
 Nervous system diseases | 7 (15.21%) | 53 (12.77%) | 0.635 |
 Immunodeficiency | 4 (8.7%) | 22 (5.3%) | 0.341 |
Infection Site | |||
 Pulmonary | 26 (56.52%) | 255 (61.45%) | 0.529 |
 Intra-abdominal | 11 (23.91%) | 101 (24.34%) | 0.956 |
 Perioperative prevention | 6 (13.04%) | 43 (10.36%) | 0.572 |
 Skin or soft tissue | 2 (4.35%) | 19 (4.58%) | 0.946 |
 Urinary tract | 3 (6.52%) | 17 (4.1%) | 0.451 |
 Intracranial | 1 (2.17%) | 8 (1.93%) | 0.907 |
No. of prescribed drugs per patient | 38 (27, 39) | 32 (20, 33.5) | < 0.001 |
No. of antimicrobials per patient | 6 (5, 8) | 3 (2, 6) | < 0.001 |
No. of pDDIs per patient | 2 (2, 3) | 2 (1, 2) | 0.057 |