Table 5 Subgroup analysis of the pDDI among elderly patients in Africa
From: Drug-drug interaction among elderly patients in Africa: a systematic review and meta-analysis
Variable | Subgroup | Number of studies | Prevalence (95% CI) | Heterogeneity | |
|---|---|---|---|---|---|
I2% | p value | ||||
Country | Ethiopia | 7 | 50.61 (23.94, 77.27) | 99.6 | 0.000 |
Nigeria | 4 | 43.45 (11.10, 75.79) | 99.4 | 0.000 | |
South Africa | 2 | 83.81 (79.89, 87.72) | 0.0 | 0.357 | |
Other | 2 | 47.47 (-0.45, 95.39) | 99.3 | 0.000 | |
Study design | Retrospective cross- sectional | 8 | 52.21 (26.62, 77.81) | 99.6 | 0.000 |
Prospective observational | 2 | 44.35 (17.42, 71.28) | 98.4 | 0.000 | |
Cross-sectional | 5 | 56.39 (16.78, 96.01) | 99.7 | 0.000 | |
Database | Medscape online | 4 | 57.69 (33.66, 81.72) | 98.8 | 0.000 |
Beers criteria | 3 | 31.97 (9.34, 54.60) | 99.4 | 0.000 | |
Micromedex Medscape online & Epocrates | 2 2 | 43.39 (6.84, 79.94) 66.23 (29.77, 102.68) | 98.5 99.1 | 0.000 0.000 | |
Other* | 4 | 52.53 (35.40, 85.16) | 98.5 | 0.000 | |
Number of database used | Single | 9 | 45.06 (25.57, 64.56) | 99.6 | 0.000 |
Two | 6 | 63.67 (44.30, 83.04) | 98.6 | 0.000 | |
Pathology | CVDs | 3 | 74.56 (46.19, 102.94) | 98.4 | 0.000 |
All conditions | 11 | 46.22 (27.39, 65.05) | 99.6 | 0.000 | |
BPH | 1 | 55.80 (48.93, 62.67) | - | - | |
Setting | Outpatients | 9 | 58.07 (32.23, 83.91) | 99.6 | 0.000 |
Inpatients | 4 | 43.38 (24.98, 61.78) | 97.7 | 0.000 | |
Both settings | 2 | 45.97 (-33.03, 124.97) | 99.9 | 0.000 | |