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Table 2 Pharmacokinetic parameters of riluzole (N = 72)

From: A study on the pharmacokinetic bioequivalence of oral tablet formulations of riluzole among healthy volunteers utilizing HPLC-MS/MS

Pharmacokinetic parameters (units)

Mean ± SD (CV%)

Test preparation(T)

Reference preparation(R)

Tmax(h)

0.83(0.33,4.00)

0.83(0.33,6.00)

Cmax(ng/mL)

244 ± 133(54.3)

228 ± 125(54.8)

AUC0 − t(h*ng/mL)

818 ± 372(45.4)

799 ± 376(47.1)

AUC0−∞(h*ng/mL)

845 ± 385(45.5)

825 ± 387(46.9)

AUC_%Extrap(%)

3.3 ± 1.4(41.5)

3.4 ± 1.8(53.6)

λz(1/h)

0.0620 ± 0.00901(14.5)

0.0622 ± 0.00928(14.9)

t1/2(h)

11.4 ± 1.84(16.1)

11.4 ± 1.94(17.0)

  1. Tmax is expressed as median (minimum, maximum)h, hour; Cmax, maximum plasma concentration; AUC0 − t is area under the curve from time 0 to the time of the last measurable concentration; AUC0 − r is area under the curve from time 0 to infinity; AUC_%Extrap, percentage of the area under the curve extrapolated to infinity; λz, terminal elimination rate; t1/2, elimination half-life; N, number of cases participating in the calculation
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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