A study on the pharmacokinetic bioequivalence of oral tablet formulations of riluzole among healthy volunteers utilizing HPLC-MS/MS

Table 3 Bioequivalence results of main pharmacokinetic parameters of riluzole (N = 72)

Pharmacokinetic parameters(Unit)	Geometric mean and ratio			CV (%)	90% CI (%)
Pharmacokinetic parameters(Unit)	Test preparation(T)	Reference preparation(R)	T/R (%)	CV (%)	90% CI (%)
C_max (ng/mL)	210	195	107.67	45.83	95.37-121.55
AUC_0 − t (h*ng/mL)	741	718	103.11	20.02	97.59-108.95
AUC_0−∞ (h*ng/mL)	766	744	102.93	19.35	97.59-108.56

CV, Coefficient of Variation; CI, confidence interval; C_max, maximum plasma concentration; AUC_0 − t is area under the curve from time 0 to the time of the last measurable concentration; AUC_0−∞ is area under the curve from time 0 to infinity

ISSN: 2050-6511