Table 6 Percentage recovery of impurities from spiked sample solution of Fosamprenavir
% Level | Percentage Recovery (%) *Mean ± SD | ||||
|---|---|---|---|---|---|
Amino impurity | Propyl impurity | Isomer impurity | Nitro impurity | Amprenavir impurity | |
LOQ | 97.93 ± 1.85 | 100.10 ± 1.37 | 100.30 ± 1.00 | 99.16 ± 1.51 | 99.63 ± 0.66 |
50 | 98.23 ± 1.09 | 98.86 ± 0.95 | 98.33 ± 0.55 | 99.26 ± 1.35 | 10.46 ± 0.30 |
100 | 99.23 ± 0.75 | 98.70 ± 1.47 | 98.93 ± 0.66 | 99.83 ± 1.00 | 99.26 ± 0.49 |
150 | 100.80 ± 0.40 | 100.93 ± 0.75 | 98.10 ± 0.81 | 99.46 ± 0.77 | 100.53 ± 0.05 |